Dynamic Regulation of Myocardium Contractility in Positive Force-Frequency Relationship
نویسندگان
چکیده
منابع مشابه
Effect of cyclopiazonic acid on the force-frequency relationship in human nonfailing myocardium.
The present study investigated the functional role of the sarcoplasmic reticulum Ca++-ATPase in contraction and relaxation, intracellular Ca++-transients, as well as on the force-frequency relationship in human myocardium. The Ca++-ATPase activity of membrane vesicles isolated from sarcoplasmic reticulum (SR) obtained from nonfailing donor hearts (n = 7) was measured in the presence of cyclopia...
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The way that contractility varies between beats—the force-frequency relationshipwas determined for rabbit papillary muscles held at different lengths. When the maximum rate of rise of tension in a contraction, Fmai, was used as a measure of contractility, the way contractility changed between contractions was independent of length. That is, when the values of Fmax obtained at one length were mu...
متن کاملForce-frequency relationship. A basis for a new index of cardiac contractility?
The way that contractility varies between beats—the force-frequency relationshipwas determined for rabbit papillary muscles held at different lengths. When the maximum rate of rise of tension in a contraction, Fmai, was used as a measure of contractility, the way contractility changed between contractions was independent of length. That is, when the values of Fmax obtained at one length were mu...
متن کاملSERCA2a activity correlates with the force-frequency relationship in human myocardium.
The present investigation addresses whether protein expression and function of sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) and phospholamban (PLB) correlate in failing and nonfailing human myocardium. SERCA2a activity and protein expression, PLB phosphorylation, and the force-frequency relationship (FFR) have been determined in right atrium (RA) and left ventricle (LV) from nonfailing ...
متن کاملEffect of thyroid hormone on the frequency-force relationship of atrial myocardium from the guinea pig.
Measurements of the frequency-force relationship were made in left atrial muscle from euthyroid and hyperthyroid guinea pigs and the effects of calcium and norepinephrine on this relationship examined. Isometric contractile force was measured with the muscle suspended in a bath of Krebs-Henseleit solution oxygenated by a gas mixture of 95£ O2-5% CO2 at 28°C. Frequency of stimulation was varied ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.1826